Opportunity Information: Apply for RFA PS 19 003
The grant opportunity titled "Using Real-time Prescription and Insurance Claims Data to Support the HIV Care Continuum" (Funding Opportunity Number RFA PS 19 003) is a Centers for Disease Control and Prevention (CDC) cooperative agreement issued under the U.S. Department of Health and Human Services. It sits within the health funding activity area (CFDA 93.941) and is designed as a research-focused project that applies real-time medical and pharmacy claims data to strengthen key points along the HIV care continuum, especially medication adherence, retention in care, and timely initiation or continuation of antiretroviral therapy (ARV/ART). The core idea is to use routinely generated insurance and prescription claims as a near-real-time signal to identify gaps in treatment and then use those signals to prompt targeted public health or care interventions.
The opportunity supports two related but distinct categories of work. Category A focuses on identifying people with diagnosed HIV who appear to have stopped filling their ARV prescriptions. Using pharmacy claims data, the project aims to detect when refill patterns suggest treatment interruption or disengagement, and then to use that information to target those individuals for adherence and retention interventions. In practical terms, this category is about creating a timely, data-driven way to spot lapses in ART pickup before they become long-term disengagement, with the expectation that earlier identification allows quicker outreach, re-engagement, and clinical follow-up.
Category B focuses on identifying persons living with HIV, including pregnant women, and ensuring they are receiving ARV therapy by leveraging both medical and pharmacy claims. While Category A is centered on refill discontinuation among known patients, Category B emphasizes broader identification and verification that ART is being provided, using claims across settings. Including pregnant women highlights prevention of perinatal HIV transmission and the importance of rapid initiation and sustained use of ART during pregnancy. This category points to using claims as a monitoring and confirmation tool: whether someone with HIV has evidence of ART prescribing and dispensing, and whether there are signals in medical claims that indicate HIV care engagement or gaps.
The award is structured as a cooperative agreement, meaning the CDC is expected to have substantial involvement in the funded work rather than acting only as a pass-through funder. Cooperative agreements typically involve collaboration on project direction, performance expectations, and public health application of results. The funding ceiling is $1,100,000 per award, with an expectation of two total awards, indicating a relatively small number of funded projects with enough resources to build or enhance data systems, analytic approaches, and intervention workflows tied to the claims-based signals.
Eligibility is broad and includes multiple levels of government (state, county, city/township, special districts), public and private institutions of higher education, federally recognized tribal governments and certain tribal organizations, public housing authorities/Indian housing authorities, a wide range of nonprofit organizations (both 501(c)(3) and non-501(c)(3)), and for-profit entities including small businesses. This wide eligibility suggests the CDC anticipated applications from health departments, academic-public health partnerships, healthcare analytics organizations, and other entities capable of accessing, managing, and analyzing claims data and coordinating follow-up interventions with clinical or community partners.
Key administrative details included that the opportunity was created on November 9, 2018, with an original application closing date of January 22, 2019, and electronic applications due by 5:00 p.m. Eastern Time on the due date. Overall, the program is aimed at demonstrating and evaluating how real-time claims data can be operationalized for public health action to improve ART continuity, retention in HIV care, and assurance of ART coverage for people living with HIV, with particular attention to time-sensitive populations such as pregnant women.Apply for RFA PS 19 003
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Using Real-time Prescription and Insurance Claims Data to Support the HIV Care Continuum" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.941.
- This funding opportunity was created on Nov 09, 2018.
- Applicants must submit their applications by Jan 22, 2019 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,100,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the purpose of the grant opportunity "Using Real-time Prescription and Insurance Claims Data to Support the HIV Care Continuum"?
This CDC cooperative agreement supports research-focused projects that use near-real-time medical and pharmacy insurance claims data to strengthen key points along the HIV care continuum. The goal is to use routinely generated claims as timely signals to identify gaps in treatment or care engagement and then use those signals to prompt targeted public health or care interventions, especially to improve medication adherence, retention in care, and timely initiation or continuation of antiretroviral therapy (ARV/ART).
What is the Funding Opportunity Number for this grant?
The Funding Opportunity Number is RFA PS 19 003.
Which federal agency is offering this grant?
The opportunity is issued by the Centers for Disease Control and Prevention (CDC) under the U.S. Department of Health and Human Services.
What is the CFDA number and funding activity area?
The opportunity sits within the health funding activity area and is associated with CFDA 93.941.
What type of award is this (grant vs. cooperative agreement)?
This award is structured as a cooperative agreement. That means CDC is expected to have substantial involvement in the funded work, typically including collaboration on project direction, performance expectations, and the public health application of results.
How does the opportunity propose to use claims data in HIV public health work?
The project concept is to treat insurance and prescription claims as a near-real-time signal. By analyzing these routinely generated data streams, recipients can identify likely treatment interruptions or care gaps and use those signals to trigger targeted outreach, re-engagement, adherence support, and clinical follow-up.
What are the main focus areas along the HIV care continuum for this opportunity?
The opportunity emphasizes improving medication adherence, retention in HIV care, and the timely initiation or continuation of ARV/ART.
What are the two categories of work supported under this opportunity?
The opportunity supports two related categories: Category A and Category B. Category A focuses on identifying people with diagnosed HIV who appear to have stopped filling ARV prescriptions based on pharmacy claims. Category B focuses on identifying persons living with HIV (including pregnant women) and ensuring they are receiving ARV therapy using both medical and pharmacy claims.
What is Category A focused on?
Category A focuses on identifying people with diagnosed HIV who appear to have stopped filling their ARV prescriptions. It uses pharmacy claims data to detect refill patterns that suggest treatment interruption or disengagement and then targets those individuals for adherence and retention interventions.
What is the practical intent behind Category A?
The practical intent is to create a timely, data-driven way to spot lapses in ART pickup before they become long-term disengagement. The expectation is that earlier identification enables quicker outreach, re-engagement, and clinical follow-up.
What is Category B focused on?
Category B focuses on identifying persons living with HIV, including pregnant women, and ensuring they are receiving ARV therapy. It leverages both medical and pharmacy claims data to support broader identification and verification that ART is being provided.
How is Category B different from Category A?
Category A centers on refill discontinuation among people already known to have diagnosed HIV, using pharmacy refill patterns as a signal. Category B emphasizes broader identification and confirmation of ART receipt using claims across settings (medical and pharmacy), including monitoring for signals of HIV care engagement or gaps.
Why are pregnant women specifically mentioned in Category B?
Including pregnant women highlights prevention of perinatal HIV transmission and the importance of rapid initiation and sustained use of ART during pregnancy, where timely monitoring and quick intervention are particularly important.
What data sources are central to this opportunity?
The opportunity is centered on routinely generated pharmacy claims and medical claims, used as near-real-time indicators of ART prescribing/dispensing and signals related to HIV care engagement or gaps.
What is the maximum funding amount per award?
The funding ceiling is $1,100,000 per award.
How many awards are expected to be made?
There is an expectation of two total awards.
What kinds of activities might the award support, based on the description?
Based on the description, funded projects may involve building or enhancing data systems, developing analytic approaches to detect treatment interruptions or gaps, and creating intervention workflows that use claims-based signals to prompt outreach and follow-up actions tied to adherence, retention, and ART coverage.
Who is eligible to apply for this opportunity?
Eligibility is broad and includes multiple levels of government (state, county, city/township, special districts), public and private institutions of higher education, federally recognized tribal governments and certain tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), and for-profit entities including small businesses.
What types of organizations does the broad eligibility suggest CDC expected to apply?
The broad eligibility suggests CDC anticipated applications from health departments, academic-public health partnerships, healthcare analytics organizations, and other entities capable of accessing, managing, and analyzing claims data and coordinating follow-up interventions with clinical or community partners.
When was the opportunity created?
The opportunity was created on November 9, 2018.
What was the original application closing date?
The original application closing date was January 22, 2019.
When were electronic applications due on the closing date?
Electronic applications were due by 5:00 p.m. Eastern Time on the due date.
What is the overall program aim?
The overall aim is to demonstrate and evaluate how real-time claims data can be operationalized for public health action to improve ART continuity, retention in HIV care, and assurance of ART coverage for people living with HIV, with particular attention to time-sensitive populations such as pregnant women.
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