Opportunity Information: Apply for PAR 19 249
The National Institutes of Health (NIH) funding opportunity announcement PAR-19-249, titled "Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed)," supports research that looks at how extreme weather and disaster-related events influence the fundamental biological mechanisms of aging. The program is focused on basic biology, with the intent to build a stronger scientific foundation for understanding how exposures tied to events like heat waves, hurricanes, wildfires, floods, drought, severe storms, and related disasters may accelerate, modify, or otherwise shape aging processes. A central feature of this opportunity is that it is designed for studies in laboratory animals, with the explicit goal of generating mechanistic evidence that can complement and inform a companion NIH opportunity aimed at examining adverse outcomes in older adults and across the aging life course.
This FOA uses the NIH R01 grant mechanism and is categorized as a discretionary grant program within the environment and health activity space. The emphasis on animal-based studies signals that NIH is looking for projects that can experimentally isolate specific environmental stressors or disaster-associated exposures and then measure their downstream effects on biological aging pathways. In practice, that can include work that probes stress response biology, inflammation and immune dysregulation, oxidative stress, mitochondrial function, cellular senescence, epigenetic changes, metabolic disruption, proteostasis, neuroendocrine signaling, and other hallmark processes linked to aging. Because disasters and extreme weather events often involve complex exposure mixtures (for example, heat plus dehydration, smoke inhalation plus psychosocial stress, or flood contamination plus infectious risk), the program is well suited to studies that model single exposures or carefully controlled combinations to clarify cause-and-effect relationships and identify potential biological targets for prevention or resilience.
Clinical trials are not allowed under this announcement, which means proposed research should not be designed as a clinical intervention study in humans. Instead, applicants are expected to propose preclinical, mechanistic, and translationally relevant animal research that can help explain why older organisms may be more vulnerable to extreme events or how repeated exposures over time might alter trajectories of biological aging. The work is intended to provide insights that can be carried into human observational research and public health planning through the companion FOA, helping bridge the gap between population-level impacts of disasters and the underlying biology that drives heightened risk in aging.
Eligibility is broad across U.S.-based organizations and includes state, county, city, township, and special district governments; federally recognized tribal governments; public housing authorities and Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not higher-education institutions in those categories); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and tribal governments that are not federally recognized (as listed in the announcement). At the same time, there are clear restrictions related to foreign involvement: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. In other words, applications must be fully domestic in both applicant organization and project components.
From the administrative details provided, the sponsoring agency is NIH, and the opportunity is associated with CFDA numbers 93.113 and 93.866. The funding opportunity was created on April 11, 2019, and the original closing date listed is March 8, 2021. The listing does not specify an award ceiling or the expected number of awards in the provided fields, so prospective applicants would typically look to the full FOA and NIH Institute/Center budget guidance for the most accurate expectations about allowable budgets, project periods, and the scope NIH anticipates supporting.
Overall, this opportunity is aimed at strengthening the evidence base around how extreme environmental events affect aging at a biological level, using laboratory animal models to identify mechanisms, pathways, and potentially modifiable factors that shape vulnerability and resilience. The larger public health motivation behind it is to improve understanding of why aging populations face disproportionate harms from extreme weather and disasters and to generate mechanistic knowledge that can guide future research, preparedness, and risk-reduction strategies.Apply for PAR 19 249
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.866.
- This funding opportunity was created on 2019-04-11.
- Applicants must submit their applications by 2021-03-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 19 009 Funding Number: RFA ES 19 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed) Apply for RFA ES 19 010 Funding Number: RFA ES 19 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed) Apply for RFA ES 19 004 Funding Number: RFA ES 19 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trial Not Allowed) Apply for RFA ES 19 003 Funding Number: RFA ES 19 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Pregnancy as a Vulnerable Time Period for Women's Health (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 003 Funding Number: RFA ES 20 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $300,000 |
| Limited Competition: Specialized Centers of Excellence on Environmental Health Disparities Research (P50) Apply for RFA MD 20 001 Funding Number: RFA MD 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $950,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R01 Clinical Trial Not Allowed) Apply for PAR 19 386 Funding Number: PAR 19 386 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R21 Clinical Trial Not Allowed) Apply for PAR 19 385 Funding Number: PAR 19 385 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 005 Funding Number: RFA ES 20 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for RFA ES 20 002 Funding Number: RFA ES 20 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 20 006 Funding Number: RFA ES 20 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 20 009 Funding Number: RFA ES 20 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| U.S. - India Collaborative Environmental Health Research Program (R01 Clinical Trial Optional) Apply for RFA ES 20 010 Funding Number: RFA ES 20 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 012 Funding Number: RFA ES 20 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Collaborative Centers in Children's Environmental Health Research and Translation Centers (P2C Clinical Trial Optional) Apply for RFA ES 20 001 Funding Number: RFA ES 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| RESolution of InflammaTion in EnvirOnmentally Related diseasE (RESTORE) (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 013 Funding Number: RFA ES 20 013 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $350,000 |
| NIEHS SBIR Phase IIB Validation of Sensors for Improved Environmental Exposure Assessment (R44 Clinical Trial Not Allowed) Apply for RFA ES 20 016 Funding Number: RFA ES 20 016 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Pediatric and Reproductive Environmental Health Scholars (PREHS): Strengthening the Pipeline (K12 Clinical Trial Not Allowed) Apply for RFA ES 20 007 Funding Number: RFA ES 20 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $450,000 |
| Utilizing In Vitro Functional Genomics Advances for Gene-Environment (G x E) Discovery and Validation (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 018 Funding Number: RFA ES 20 018 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $499,999 |
| Outstanding New Environmental Scientist (ONES) Award (R01 Clinical Trial Optional) Apply for RFA ES 21 001 Funding Number: RFA ES 21 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
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