Opportunity Information: Apply for PAR 19 249
The National Institutes of Health (NIH) funding opportunity announcement PAR-19-249, titled "Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed)," supports research that looks at how extreme weather and disaster-related events influence the fundamental biological mechanisms of aging. The program is focused on basic biology, with the intent to build a stronger scientific foundation for understanding how exposures tied to events like heat waves, hurricanes, wildfires, floods, drought, severe storms, and related disasters may accelerate, modify, or otherwise shape aging processes. A central feature of this opportunity is that it is designed for studies in laboratory animals, with the explicit goal of generating mechanistic evidence that can complement and inform a companion NIH opportunity aimed at examining adverse outcomes in older adults and across the aging life course.
This FOA uses the NIH R01 grant mechanism and is categorized as a discretionary grant program within the environment and health activity space. The emphasis on animal-based studies signals that NIH is looking for projects that can experimentally isolate specific environmental stressors or disaster-associated exposures and then measure their downstream effects on biological aging pathways. In practice, that can include work that probes stress response biology, inflammation and immune dysregulation, oxidative stress, mitochondrial function, cellular senescence, epigenetic changes, metabolic disruption, proteostasis, neuroendocrine signaling, and other hallmark processes linked to aging. Because disasters and extreme weather events often involve complex exposure mixtures (for example, heat plus dehydration, smoke inhalation plus psychosocial stress, or flood contamination plus infectious risk), the program is well suited to studies that model single exposures or carefully controlled combinations to clarify cause-and-effect relationships and identify potential biological targets for prevention or resilience.
Clinical trials are not allowed under this announcement, which means proposed research should not be designed as a clinical intervention study in humans. Instead, applicants are expected to propose preclinical, mechanistic, and translationally relevant animal research that can help explain why older organisms may be more vulnerable to extreme events or how repeated exposures over time might alter trajectories of biological aging. The work is intended to provide insights that can be carried into human observational research and public health planning through the companion FOA, helping bridge the gap between population-level impacts of disasters and the underlying biology that drives heightened risk in aging.
Eligibility is broad across U.S.-based organizations and includes state, county, city, township, and special district governments; federally recognized tribal governments; public housing authorities and Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not higher-education institutions in those categories); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and tribal governments that are not federally recognized (as listed in the announcement). At the same time, there are clear restrictions related to foreign involvement: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. In other words, applications must be fully domestic in both applicant organization and project components.
From the administrative details provided, the sponsoring agency is NIH, and the opportunity is associated with CFDA numbers 93.113 and 93.866. The funding opportunity was created on April 11, 2019, and the original closing date listed is March 8, 2021. The listing does not specify an award ceiling or the expected number of awards in the provided fields, so prospective applicants would typically look to the full FOA and NIH Institute/Center budget guidance for the most accurate expectations about allowable budgets, project periods, and the scope NIH anticipates supporting.
Overall, this opportunity is aimed at strengthening the evidence base around how extreme environmental events affect aging at a biological level, using laboratory animal models to identify mechanisms, pathways, and potentially modifiable factors that shape vulnerability and resilience. The larger public health motivation behind it is to improve understanding of why aging populations face disproportionate harms from extreme weather and disasters and to generate mechanistic knowledge that can guide future research, preparedness, and risk-reduction strategies.Apply for PAR 19 249
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.866.
- This funding opportunity was created on 2019-04-11.
- Applicants must submit their applications by 2021-03-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PAR-19-249 about?
PAR-19-249, titled "Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Processes (R01 Clinical Trial Not Allowed)," supports research on how extreme weather and disaster-related events influence the fundamental biological mechanisms of aging. The emphasis is on building mechanistic, basic-biology evidence showing how these exposures may accelerate, modify, or otherwise shape aging processes.
What is the main scientific focus of this program?
The program is focused on basic biology of aging. It prioritizes mechanistic studies that can clarify cause-and-effect relationships between disaster-related environmental stressors (alone or in controlled combinations) and biological aging pathways.
What types of events or exposures does NIH consider relevant under this FOA?
The opportunity highlights extreme weather and disaster events such as heat waves, hurricanes, wildfires, floods, drought, severe storms, and related disasters. The associated exposures can include complex mixtures (for example, heat plus dehydration, smoke inhalation plus psychosocial stress, or flood contamination plus infectious risk), as long as they can be modeled in a way that supports mechanistic conclusions.
What grant mechanism does this opportunity use?
This FOA uses the NIH R01 grant mechanism.
Are clinical trials allowed?
No. Clinical trials are not allowed under this announcement. Proposed research should not be designed as a clinical intervention study in humans.
Does this FOA support human studies?
Based on the information provided, the central feature of this opportunity is laboratory animal research designed to generate mechanistic evidence. The FOA is positioned to complement a companion NIH opportunity focused on adverse outcomes in older adults and across the aging life course, but this FOA itself is explicitly oriented toward animal-based mechanistic studies and does not allow clinical trials.
What research approaches are especially aligned with this FOA?
Approaches that experimentally isolate specific environmental stressors or disaster-associated exposures in laboratory animals and measure downstream effects on biological aging pathways are especially aligned. The program is well suited to studies that model single exposures or carefully controlled combinations to clarify biological mechanisms.
What aging-related biological mechanisms or pathways could be studied?
The FOA description indicates interest in mechanistic work that may include (but is not limited to) stress response biology, inflammation and immune dysregulation, oxidative stress, mitochondrial function, cellular senescence, epigenetic changes, metabolic disruption, proteostasis, neuroendocrine signaling, and other hallmark processes linked to aging.
Why does NIH emphasize laboratory animal studies for this topic?
The emphasis on animal-based studies reflects NIH interest in generating mechanistic evidence under controlled experimental conditions. This can help explain why older organisms may be more vulnerable to extreme events and how repeated exposures over time might alter trajectories of biological aging, creating a stronger foundation to inform observational human research and public health planning.
How does this FOA relate to other NIH efforts on disasters and aging?
This opportunity is described as complementary to a companion NIH opportunity aimed at examining adverse outcomes in older adults and across the aging life course. The intent is for mechanistic animal evidence generated here to complement and inform that human-focused work.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations. Eligible applicants include state, county, city, township, and special district governments; federally recognized tribal governments; public housing authorities and Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (as long as they are not higher-education institutions in those categories); for-profit organizations other than small businesses; and small businesses.
Are minority-serving or special-designation institutions included in the eligible applicant types?
Yes. The FOA explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and tribal governments that are not federally recognized (as listed in the announcement).
Are foreign organizations or foreign components allowed?
No. The FOA includes clear restrictions: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply; non-U.S. components of U.S. organizations are not eligible; and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. Applications must be fully domestic in both the applicant organization and the project components.
What agency sponsors this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What program area does this opportunity fall under?
It is described as a discretionary grant program within the environment and health activity space, focused on environmental influences on aging in the context of extreme weather and disaster events.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.113 and 93.866.
When was this funding opportunity created, and what is the listed closing date?
The funding opportunity was created on April 11, 2019, and the original closing date listed is March 8, 2021.
Does the listing provide an award ceiling or the expected number of awards?
No. In the provided administrative fields, the listing does not specify an award ceiling or the expected number of awards. Prospective applicants would typically refer to the full FOA and relevant NIH Institute/Center budget guidance for expectations about allowable budgets, project periods, and scope.
What is the overarching goal or public health motivation behind this FOA?
The larger motivation is to strengthen the evidence base for how extreme environmental events affect aging at a biological level, and to improve understanding of why aging populations face disproportionate harms from extreme weather and disasters. The mechanistic knowledge generated is intended to guide future research, preparedness, and risk-reduction strategies.
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| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed) Apply for RFA ES 19 010 Funding Number: RFA ES 19 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed) Apply for RFA ES 19 004 Funding Number: RFA ES 19 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Hazardous Materials Worker Health and Safety Training (U45 Clinical Trial Not Allowed) Apply for RFA ES 19 003 Funding Number: RFA ES 19 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Pregnancy as a Vulnerable Time Period for Women's Health (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 003 Funding Number: RFA ES 20 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $300,000 |
| Limited Competition: Specialized Centers of Excellence on Environmental Health Disparities Research (P50) Apply for RFA MD 20 001 Funding Number: RFA MD 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $950,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R01 Clinical Trial Not Allowed) Apply for PAR 19 386 Funding Number: PAR 19 386 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Risks for Psychiatric Disorders: Biological Basis of Pathophysiology (R21 Clinical Trial Not Allowed) Apply for PAR 19 385 Funding Number: PAR 19 385 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 005 Funding Number: RFA ES 20 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) Apply for RFA ES 20 002 Funding Number: RFA ES 20 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHSCC) (P30 Clinical Trial Optional) Apply for RFA ES 20 006 Funding Number: RFA ES 20 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) (R35 Clinical Trial Optional) Apply for RFA ES 20 009 Funding Number: RFA ES 20 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| U.S. - India Collaborative Environmental Health Research Program (R01 Clinical Trial Optional) Apply for RFA ES 20 010 Funding Number: RFA ES 20 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 20 012 Funding Number: RFA ES 20 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Collaborative Centers in Children's Environmental Health Research and Translation Centers (P2C Clinical Trial Optional) Apply for RFA ES 20 001 Funding Number: RFA ES 20 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| RESolution of InflammaTion in EnvirOnmentally Related diseasE (RESTORE) (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 013 Funding Number: RFA ES 20 013 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $350,000 |
| NIEHS SBIR Phase IIB Validation of Sensors for Improved Environmental Exposure Assessment (R44 Clinical Trial Not Allowed) Apply for RFA ES 20 016 Funding Number: RFA ES 20 016 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Pediatric and Reproductive Environmental Health Scholars (PREHS): Strengthening the Pipeline (K12 Clinical Trial Not Allowed) Apply for RFA ES 20 007 Funding Number: RFA ES 20 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $450,000 |
| Utilizing In Vitro Functional Genomics Advances for Gene-Environment (G x E) Discovery and Validation (R01 Clinical Trial Not Allowed) Apply for RFA ES 20 018 Funding Number: RFA ES 20 018 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $499,999 |
| Outstanding New Environmental Scientist (ONES) Award (R01 Clinical Trial Optional) Apply for RFA ES 21 001 Funding Number: RFA ES 21 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
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