Opportunity Information: Apply for RFA HL 17 031
Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM2) (RFA HL 17 031) is a National Institutes of Health (NIH) funding opportunity, developed with participation from relevant NIH Institutes and Centers and the U.S. Food and Drug Administration (FDA), that specifically calls for competing revision applications to certain existing NIH cooperative agreement awards. The core idea is not to fund brand-new standalone projects, but to provide additional support during an active budget period so an already-funded UM2 award can expand its approved scope or modify and extend an existing research protocol. In other words, this is an opportunity for teams that are already running NIH-supported program projects or complex centers under the UM2 mechanism to add a focused, innovation-oriented clinical research component that strengthens regenerative medicine development.
The scientific emphasis is on regenerative medicine approaches that use adult stem cells, with the expectation that proposed additions will meaningfully advance the field by addressing practical, widely recognized barriers to producing safe and effective regenerative medicine therapies. The FOA highlights that the most competitive revisions will tackle problems that tend to slow translation from the laboratory into real-world clinical use, especially problems that show up when products move toward regulatory review and eventual patient access. Because FDA is a participating partner, a major theme is regulatory relevance: applications are encouraged to generate evidence, tools, or methods that can support or strengthen future regulatory submissions by improving how products are developed, characterized, manufactured, and evaluated.
Projects supported under this revision call are expected to be innovative and solutions-driven rather than purely descriptive. The opportunity points applicants toward work that improves the technical and scientific foundation needed to assess regenerative medicine products with greater confidence. Examples of the kinds of contributions the FOA is aiming at include improved tools, methods, and standards, as well as applied science that helps the field better understand and evaluate manufacturing processes, product quality attributes, and clinical or nonclinical indicators of safety and effectiveness. The intent is to make regenerative medicine products more reproducible and interpretable across development stages, and to reduce uncertainty around how a therapy is made and how it performs.
Administratively, this FOA is a discretionary grant opportunity using the Cooperative Agreement funding instrument, meaning NIH anticipates substantial programmatic involvement compared with a standard research project grant. The eligible applicant types are broad and include many government entities (state, county, city/township, special districts), public and private institutions of higher education, federally recognized tribal governments and certain tribal organizations, public housing authorities/Indian housing authorities, a wide range of nonprofit organizations (including both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and other applicants as allowed under the announcement’s additional eligibility language. However, the practical eligibility constraint is more specific: the revision request must come from investigators who already hold active UM2 Program Project or Center with Complex Structure Cooperative Agreement awards, since the mechanism is designed to expand ongoing UM2-supported activities rather than initiate new ones.
Key dates and funding details indicate this was posted on April 28, 2017, with an original closing date of June 26, 2017. The listed award ceiling is $324,500, and NIH anticipated making about six awards. The opportunity is associated with multiple CFDA numbers spanning several NIH programs, reflecting multi-institute participation and the cross-cutting nature of regenerative medicine development. Overall, the FOA is best read as a targeted infusion of supplemental, competitively reviewed support for existing UM2 centers and program projects to pursue clinically oriented, adult stem cell-based regenerative medicine innovations that directly address development and regulatory science bottlenecks in manufacturing, quality, safety, and effectiveness evaluation.Apply for RFA HL 17 031
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM2)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.242, 93.286, 93.350, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.856, 93.866, 93.867.
- This funding opportunity was created on Apr 28, 2017.
- Applicants must submit their applications by Jun 26, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $324,500.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
|---|
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM1) Apply for RFA HL 17 026 Funding Number: RFA HL 17 026 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (U54) Apply for RFA HL 17 025 Funding Number: RFA HL 17 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R01) Apply for RFA HL 17 029 Funding Number: RFA HL 17 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (P50) Apply for RFA HL 17 032 Funding Number: RFA HL 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R24) Apply for RFA HL 17 030 Funding Number: RFA HL 17 030 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (U01) Apply for RFA HL 17 034 Funding Number: RFA HL 17 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (P41) Apply for RFA HL 17 033 Funding Number: RFA HL 17 033 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Cystic Fibrosis Research and Translation Center (P30) Apply for RFA DK 17 007 Funding Number: RFA DK 17 007 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| NIDDK Information Network Coordinating Unit: dkNET-CU (U24) Apply for RFA DK 17 010 Funding Number: RFA DK 17 010 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $635,000 |
| Limited Competition for the Continuation of the Drug Induced Liver Injury Network Data Coordinating Center (U24) Apply for RFA DK 17 510 Funding Number: RFA DK 17 510 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $900,000 |
| Limited Competition for the Continuation of the Drug Induced Liver Injury Network (DILIN) Clinical Centers (U01) Apply for RFA DK 17 509 Funding Number: RFA DK 17 509 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Chronic Kidney Disease in Children Central Biochemistry Laboratory (U24) Apply for RFA DK 17 034 Funding Number: RFA DK 17 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases (DP1- Clinical Trial Not Allowed) Apply for RFA DK 17 011 Funding Number: RFA DK 17 011 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK Partnerships with Professional Societies to Enhance Scientific Workforce Diversity and Promote Scientific Leadership (R25) Apply for RFA DK 17 015 Funding Number: RFA DK 17 015 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $135,000 |
| Diabetic Foot Consortium - Clinical Research Units (U01) Apply for RFA DK 17 014 Funding Number: RFA DK 17 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $275,000 |
| Lymphatics in Health and Disease in the Digestive System (R01 - Clinical Trials Not Allowed) Apply for RFA DK 17 016 Funding Number: RFA DK 17 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $499,999 |
| Multidisciplinary Urologic Research (KURe) Career Development Program (K12 Clinical Trial Optional) Apply for RFA DK 17 012 Funding Number: RFA DK 17 012 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| George M. O'Brien Urology Cooperative Research Centers Program (U54-Clinical Trial Optional) Apply for RFA DK 17 013 Funding Number: RFA DK 17 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional) Apply for RFA DK 18 001 Funding Number: RFA DK 18 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Funding For Collaborative Clinical Research In Type 1 Diabetes: Living Biobank (R01 Clinical Trial Optional) Apply for RFA DK 17 032 Funding Number: RFA DK 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
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