Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) | RFA CA 22 005

Opportunity Information: Apply for RFA CA 22 005

This funding opportunity, RFA-CA-22-005, is a National Institutes of Health (NIH) announcement from the National Cancer Institute (NCI) that supports revision applications to existing, currently funded NCI R01 research awards. In practical terms, it is not aimed at brand-new standalone projects; it is designed for research teams that already have an active NCI R01 and want to formally expand or strengthen that parent project by adding a new technology component.

The central goal is to accelerate the scientific progress of the parent R01 by incorporating a novel technical approach or instrument that was developed with support from the NCI Innovative Molecular Analysis Technologies (IMAT) program. Applicants are expected to use the IMAT-supported technology to extend the original research questions, enable new experiments that were not previously feasible, improve the quality or speed of data generation, or otherwise push the parent study forward more quickly than would be possible with the existing methods. A key emphasis is on bringing promising emerging tools into wider use in the cancer research community, rather than leaving them confined to early-stage development settings.

A major purpose of the awards is to incentivize independent validation and encourage broader adoption of these IMAT-derived technologies. That means the revised scope should do more than simply purchase or try out a new tool; it should demonstrate credible, well-justified plans to test the technology in an independent research context and show how it improves measurement, analysis, or experimental capability in ways that matter for cancer research. Because the FOA is positioned as part of the IMAT program, it also highlights interdisciplinary collaboration, reflecting the idea that impactful technology adoption in cancer research often requires coordination across domains such as engineering, chemistry, computational science, molecular biology, pathology, and clinical research.

The opportunity uses the R01 grant mechanism and is listed as "Clinical Trial Optional," meaning applicants may propose a study that includes a clinical trial if it is appropriate for the proposed revision, but a clinical trial is not required. The funding instrument type is a grant, and the activity category is listed under Education and Health. The CFDA number associated with the opportunity is 93.394, which corresponds to NCI research support.

Eligibility is broad and includes many types of domestic U.S. organizations as well as certain non-U.S. entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations that are not federally recognized. The FOA also allows nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education when specified), as well as for-profit organizations (other than small businesses) and small businesses. It explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This framing signals an interest in reaching a wide range of institutions and communities capable of advancing cancer research through technology integration.

From the administrative details provided, the opportunity was created on January 3, 2022, and the original closing date was September 22, 2022. The listed award ceiling is $150,000, indicating that revisions supported under this FOA are intended to be targeted, additive investments that enable the technology integration and validation work rather than fully funding an entirely new multi-year program. The announcement lists "Expected Awards" without a number in the provided text, so the total number of funded revisions is not specified here.

Overall, this FOA is best understood as a focused add-on funding opportunity for active NCI R01 projects that can meaningfully speed up or expand their cancer research by bringing in an IMAT-supported technology, while also helping the broader field by independently validating and accelerating adoption of new NCI-backed research tools.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
• This funding opportunity was created on 2022-01-03.
• Applicants must submit their applications by 2022-09-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $150,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA CA 22 005

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