Opportunity Information: Apply for PA 21 260
The PHS 2021-2 Omnibus Solicitation from the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) is a Small Business Innovation Research (SBIR) funding opportunity designed to support U.S. small businesses that can advance biomedical, behavioral, clinical, and public health-related research and development priorities. Issued as a Parent SBIR announcement using the R43 (Phase I) and R44 (Phase II) mechanisms, it is meant to serve as a broad entry point for many different technology areas rather than being limited to a single disease or product category. Applicants are expected to align their proposed work with the missions and program interests of one or more participating NIH Institutes and Centers (and CDC components where applicable), and to select a topic area from the PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics list that corresponds to those interests.
A defining feature of this specific Parent announcement is that it is “Clinical Trial Required,” meaning the application must include at least one clinical trial as part of the proposed project. In practical terms, the project should be structured around human subjects research that meets the NIH definition of a clinical trial, with clear plans for protocol-driven evaluation of an intervention or strategy and measurement of health-related or behavioral outcomes. Because clinical trials carry additional regulatory, ethical, and operational expectations, applicants should be prepared to address clinical trial planning elements such as study design, participant eligibility, recruitment and retention, data management, safety monitoring, and compliance requirements. The intent is to move beyond preclinical or purely technical development and into human testing that directly supports translation, feasibility, validation, or early evidence of effectiveness, depending on the project stage and the participating component’s priorities.
Eligibility is limited to U.S. small businesses that meet SBIR program requirements, reflecting the program’s purpose of stimulating technological innovation and commercialization capacity within the domestic small business sector. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. That said, “foreign components” as defined under the NIH Grants Policy Statement may be permitted in some circumstances, which generally means a portion of the project may be performed outside the United States if it is justified as necessary, adds unique value, and is allowable under NIH policy and the specific awarding component’s rules. Even when foreign components are allowed, the applicant organization itself must still be a qualifying U.S. small business, and the overall project must remain consistent with SBIR eligibility and performance requirements.
Administratively, the opportunity is categorized as a discretionary grant program and spans a wide range of public health and biomedical domains, which is reflected in the many listed CFDA numbers associated with NIH and CDC activities. The funding instrument is a grant, with no award ceiling stated in the provided listing (SBIR budgets are often guided by program policies and topic-specific expectations rather than a single universal ceiling in the summary record). The opportunity was created on July 8, 2021, and the original closing date shown is April 5, 2022. Applications submitted under this Parent SBIR solicitation are expected to propose R and D that is scientifically sound, relevant to an identified NIH/CDC topic area, and appropriate for SBIR support, typically emphasizing a pathway toward product development and commercialization such as diagnostics, therapeutics, devices, digital health tools, vaccines, or other health-related technologies, while also meeting the additional bar of including at least one clinical trial within the proposed scope.Apply for PA 21 260
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.068, 93.070, 93.073, 93.083, 93.084, 93.113, 93.136, 93.172, 93.173, 93.213, 93.233, 93.242, 93.262, 93.273, 93.279, 93.286, 93.307, 93.316, 93.326, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.840, 93.847, 93.859, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2021-07-08.
- Applicants must submit their applications by 2022-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 21 260) also looked into and applied for these:
| Funding Opportunity |
|---|
| Limited Competition: Knockout Mouse Phenotyping Project Data Coordination Center and Database (UM1 Clinical Trial Not Allowed) Apply for RFA HG 21 037 Funding Number: RFA HG 21 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Clinical Trial Not Allowed Apply for RFA HG 21 036 Funding Number: RFA HG 21 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplements to Promote Diversity in Small Businesses-SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Apply for PA 21 345 Funding Number: PA 21 345 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) Apply for PAR 22 073 Funding Number: PAR 22 073 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 22 105 Funding Number: PAR 22 105 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2022-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 22 177 Funding Number: PA 22 177 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| PHS 2022-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed) Apply for PA 22 178 Funding Number: PA 22 178 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| PHS 2022-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 22 176 Funding Number: PA 22 176 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $275,766 |
| Maternal Health Research Centers of Excellence Data Innovation and Coordinating Hub/Resource Center (U24 Clinical Trial Not Allowed) Apply for RFA HD 23 036 Funding Number: RFA HD 23 036 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence Implementation Science Hub/Resource Center (U24 Clinical Trial Optional) Apply for RFA HD 23 037 Funding Number: RFA HD 23 037 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maternal Health Research Centers of Excellence (U54 Clinical Trial Optional) Apply for RFA HD 23 035 Funding Number: RFA HD 23 035 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $17,500,000 |
| Open Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 017 Funding Number: RFA OD 22 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Laboratory Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 016 Funding Number: RFA OD 22 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Coordinating Center (U2C) (Clinical Trial Not Allowed) Apply for RFA OD 22 021 Funding Number: RFA OD 22 021 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 019 Funding Number: RFA OD 22 019 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Data Analysis Center (U24) Clinical Trial Not Allowed Apply for RFA OD 22 022 Funding Number: RFA OD 22 022 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Pregnancy and Pediatric Cohort Study Sites. Clinical Trial Not Allowed (UG3/UH3) Apply for RFA OD 22 018 Funding Number: RFA OD 22 018 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Environmental influences on Child Health Outcomes (ECHO) Measurement Core (U24) Clinical Trial Not Allowed Apply for RFA OD 22 020 Funding Number: RFA OD 22 020 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) Apply for PA 23 048 Funding Number: PA 23 048 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities (R01 - Clinical Trial Optional) Apply for PAR 23 112 Funding Number: PAR 23 112 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $500,000 |
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