Opportunity Information: Apply for RFA TS 24 010

The grant opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" (Funding Opportunity Number RFA TS 24 010; CFDA 93.061) is a discretionary research grant offered by the Department of Health and Human Services through the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry (CDC/ATSDR). Its central purpose is to fund investigator-initiated studies that improve understanding of what may contribute to the development of ALS, while also advancing the broader public health mission of the National ALS Registry. In practical terms, the program is meant to generate stronger evidence about who gets ALS, how often it occurs (both new cases each year and the number of people living with ALS at a point in time), and what factors, including environmental contributors, may influence risk.

CDC/ATSDR is particularly interested in research that identifies and evaluates potential ALS risk factors, with a stated preference for proposals focused on military service-related factors, contact sports participation, traumatic brain injury, neuroinflammation, environmental exposures, and infectious agents. These focus areas signal the types of exposures and biological pathways the agency considers especially important for near-term progress, whether that progress comes from clarifying inconsistent findings in the literature or exploring credible emerging hypotheses. The emphasis on "identify and evaluate" highlights that the agency is looking for studies that do more than describe associations; they want designs and analytic approaches that can meaningfully test, quantify, and strengthen causal inference where possible.

Applicants can propose projects under one of two distinct funding options. Funding Option A is designed for risk factor investigations that already have a solid evidence base and now need more rigorous testing, stronger study designs, improved exposure assessment, better control of confounding, replication in additional populations, or other methodological enhancements that move the science from suggestive to more definitive. Funding Option B is meant for newer, exploratory, or developmental ideas, including projects where preliminary evidence may be limited or even absent, but the concept is plausible and the work would help establish whether a line of inquiry is worth pursuing at scale. In other words, Option A leans toward validation and strengthening of existing signals, while Option B supports earlier-stage, hypothesis-generating or proof-of-concept work.

A key feature is the connection to the National ALS Registry. Applicants under either option may choose to use Registry data, but they are not required to do so, and not using Registry data will not automatically disadvantage an application. This leaves room for a wide range of study types, including analyses that leverage Registry information as well as studies relying on external cohorts, medical records, exposure databases, biorepositories, or other data sources that can help address the priority risk factor questions.

In terms of logistics and scale, the opportunity anticipated making about 8 awards, with an award ceiling of $500,000. The funding opportunity was created on August 1, 2023, and the original closing date for electronic submission was December 19, 2023, with applications due by 11:59 pm Eastern Time on the due date. Eligibility is broad and includes many types of entities: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible applicants as clarified in the full announcement. Overall, the opportunity is structured to attract a diverse set of research teams and institutions capable of producing stronger, actionable evidence about ALS risk factors, especially in the priority areas the agency has flagged.

  • The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.061.
  • This funding opportunity was created on Aug 01, 2023.
  • Applicants must submit their applications by Dec 19, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • The number of recipients for this funding is limited to 8 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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