Opportunity Information: Apply for RFA DA 25 059
The grant opportunity "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)" (Funding Opportunity Number RFA-DA-25-059) is a discretionary NIH grant focused on improving how health systems deliver care for people affected by HIV and substance use disorders. Its central goal is to fund projects that test enhanced, real-world models of care that more effectively combine HIV services, addiction treatment, and primary care into a coordinated, integrated approach. Rather than treating these needs in separate settings or disconnected programs, the opportunity emphasizes building and evaluating care models that bring these services together in ways that are more practical, accessible, and responsive to patient needs, with the larger intent of supporting efforts to "end the epidemic" by improving prevention, treatment, and long-term health outcomes.
This is an R34 mechanism, meaning it is intended for developmental and pilot-scale work that helps establish feasibility and strengthens the evidence base for larger future studies. The announcement notes "Clinical Trial Optional," which indicates applicants may propose a study that includes a clinical trial component, but they are not required to do so. In practical terms, applicants can focus on testing a service delivery model using methods that may include pragmatic trials, pilot implementation studies, or other evaluation designs appropriate for integrated care in community and clinical settings. The program sits at the intersection of education and health (Funding Activity Category: Education, Health) and is associated with CFDA number 93.279, reflecting its placement within NIH's broader portfolio.
The National Institutes of Health is the sponsoring agency. The application deadline listed is March 19, 2025. The award ceiling is $459,000, indicating the maximum expected funding per award under this announcement. The source information provided does not specify the number of expected awards, but the ceiling gives applicants a sense of the scale: this is meant to support targeted model development and testing rather than full-scale national rollouts.
A notable feature of this opportunity is the breadth of eligible applicants, which signals an interest in supporting integrated care innovations across many types of organizations and communities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses); and small businesses. In addition, the FOA explicitly highlights other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations). The inclusion of these institution types suggests a strong interest in culturally responsive, community-anchored approaches and in reaching populations that are often disproportionately affected by HIV and substance use-related harms.
In summary, this FOA funds pilot and developmental testing of integrated service delivery models that unify HIV care, addiction treatment, and primary care, with flexibility around whether a clinical trial is included. It is designed for a wide range of applicants, including community organizations, educational institutions, tribal entities, governments, and domestic or international organizations, reflecting the reality that effective integrated care can be developed and tested in many settings. The overall emphasis is on practical, testable improvements to care integration that can meaningfully advance health outcomes and strengthen systems-level responses to HIV and addiction.Apply for RFA DA 25 059
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2023-10-04.
- Applicants must submit their applications by 2025-03-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $459,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-25-059.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main purpose of this funding opportunity?
This NIH discretionary grant supports projects that develop and test enhanced, real-world models of care that integrate HIV services, addiction treatment, and primary care into a coordinated approach. The goal is to improve how health systems deliver care for people affected by HIV and substance use disorders, supporting broader efforts to improve prevention, treatment, and long-term health outcomes.
What does "integrated" care mean in the context of this FOA?
In this announcement, integrated care refers to bringing HIV services, addiction treatment, and primary care together so they are delivered in a coordinated and connected way, rather than through separate settings or disconnected programs. The emphasis is on models that are practical, accessible, and responsive to patient needs.
What type of grant mechanism is this?
This opportunity uses the R34 mechanism, which is intended for developmental and pilot-scale work. It is designed to establish feasibility and strengthen the evidence base for larger future studies.
Is a clinical trial required?
No. The FOA is labeled "Clinical Trial Optional," meaning applicants may include a clinical trial component, but they are not required to do so.
If a clinical trial is optional, what kinds of study designs are appropriate?
Based on the description provided, applicants may propose pragmatic trials, pilot implementation studies, or other evaluation designs that fit integrated care testing in community and clinical settings.
What kinds of projects does this FOA prioritize?
The FOA prioritizes pilot and developmental testing of service delivery models that better combine HIV care, addiction treatment, and primary care. The focus is on enhanced, real-world approaches that can be evaluated and that meaningfully improve care integration and patient outcomes.
What is the broader public health intent of this funding?
The opportunity is positioned under an "ending the epidemic" framing, aiming to strengthen systems-level responses to HIV and addiction by improving integrated prevention, treatment, and long-term health outcomes.
What is the Funding Activity Category associated with this opportunity?
The Funding Activity Category is Education, Health.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.279.
What is the application deadline?
The application deadline is March 19, 2025.
What is the maximum award amount (award ceiling)?
The award ceiling is $459,000, which indicates the maximum expected funding per award under this announcement.
Does the information provided specify how many awards will be made?
No. The source information provided does not specify the number of expected awards.
Who is eligible to apply?
The FOA lists a broad range of eligible applicants, including state, county, city, or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses); and small businesses.
Are tribal entities eligible to apply?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). The FOA also highlights Tribally Controlled Colleges and Universities (TCCUs).
Are community-based or faith-based organizations eligible?
Yes. The FOA explicitly highlights faith-based or community-based organizations as eligible applicants.
Are colleges and universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education. The FOA also highlights several institution types, including HBCUs, Hispanic-serving Institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, TCCUs, and other community-anchored institutions.
Are small businesses eligible?
Yes. Small businesses are included in the eligibility list.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also eligible.
Are governments eligible to apply?
Yes. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts. The FOA also highlights eligible agencies of the federal government and U.S. territories or possessions.
Are U.S. territories or possessions eligible?
Yes. The FOA explicitly highlights U.S. territories or possessions as eligible applicants.
Are non-U.S. organizations eligible?
Yes. The FOA indicates that non-U.S. entities (foreign organizations) are eligible applicants.
Why does the FOA include so many different eligible organization types?
The breadth of eligibility suggests NIH is interested in supporting integrated care innovations across many settings and communities, including culturally responsive and community-anchored approaches, and reaching populations disproportionately affected by HIV and substance use-related harms.
Is this funding intended for full-scale national rollouts?
No. The description notes this is an R34 developmental/pilot-scale opportunity, and the award ceiling suggests support for targeted model development and testing rather than large-scale national implementations.
What kinds of settings are emphasized for these projects?
The FOA emphasizes real-world models of care and mentions community and clinical settings as places where integrated care models may be tested and evaluated.
What is the core theme that ties the supported projects together?
The core theme is improving service delivery by integrating HIV services, addiction treatment, and primary care into coordinated models that are practical, accessible, and responsive, with evaluation to build evidence for future larger studies.
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