Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional) | RFA DA 25 059

Opportunity Information: Apply for RFA DA 25 059

The grant opportunity "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)" (Funding Opportunity Number RFA-DA-25-059) is a discretionary NIH grant focused on improving how health systems deliver care for people affected by HIV and substance use disorders. Its central goal is to fund projects that test enhanced, real-world models of care that more effectively combine HIV services, addiction treatment, and primary care into a coordinated, integrated approach. Rather than treating these needs in separate settings or disconnected programs, the opportunity emphasizes building and evaluating care models that bring these services together in ways that are more practical, accessible, and responsive to patient needs, with the larger intent of supporting efforts to "end the epidemic" by improving prevention, treatment, and long-term health outcomes.

This is an R34 mechanism, meaning it is intended for developmental and pilot-scale work that helps establish feasibility and strengthens the evidence base for larger future studies. The announcement notes "Clinical Trial Optional," which indicates applicants may propose a study that includes a clinical trial component, but they are not required to do so. In practical terms, applicants can focus on testing a service delivery model using methods that may include pragmatic trials, pilot implementation studies, or other evaluation designs appropriate for integrated care in community and clinical settings. The program sits at the intersection of education and health (Funding Activity Category: Education, Health) and is associated with CFDA number 93.279, reflecting its placement within NIH's broader portfolio.

The National Institutes of Health is the sponsoring agency. The application deadline listed is March 19, 2025. The award ceiling is $459,000, indicating the maximum expected funding per award under this announcement. The source information provided does not specify the number of expected awards, but the ceiling gives applicants a sense of the scale: this is meant to support targeted model development and testing rather than full-scale national rollouts.

A notable feature of this opportunity is the breadth of eligible applicants, which signals an interest in supporting integrated care innovations across many types of organizations and communities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses); and small businesses. In addition, the FOA explicitly highlights other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations). The inclusion of these institution types suggests a strong interest in culturally responsive, community-anchored approaches and in reaching populations that are often disproportionately affected by HIV and substance use-related harms.

In summary, this FOA funds pilot and developmental testing of integrated service delivery models that unify HIV care, addiction treatment, and primary care, with flexibility around whether a clinical trial is included. It is designed for a wide range of applicants, including community organizations, educational institutions, tribal entities, governments, and domestic or international organizations, reflecting the reality that effective integrated care can be developed and tested in many settings. The overall emphasis is on practical, testable improvements to care integration that can meaningfully advance health outcomes and strengthen systems-level responses to HIV and addiction.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2023-10-04.
• Applicants must submit their applications by 2025-03-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $459,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DA 25 059

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