Opportunity Information: Apply for CDC RFA OE20 20010301SUPP23

CDC-RFA-OE20-2001, "Enhancing Public Health Laboratory Capabilities and Increasing Capacity," is a CDC cooperative agreement designed to strengthen the ability of state, local, and territorial public health laboratories (PHLs) to protect communities from a wide range of health threats. The opportunity is built around the idea that PHLs are not just testing sites, but core parts of the public health system that generate the timely, credible evidence public health leaders rely on for daily decision-making. That laboratory evidence supports everything from identifying outbreaks and tracking disease trends to guiding interventions and shaping policy. Because laboratory work is tightly connected to epidemiology and broader surveillance systems, the grant emphasizes improving PHL performance both as individual laboratories and as interconnected pieces of a national public health laboratory system.

The grant recognizes that modern PHLs are expected to respond across an unusually broad and expanding mission space. This includes infectious diseases and emerging pathogens, chronic disease-related testing needs, chemical and radiological exposure events, newborn screening and other early-life testing programs, foodborne and waterborne illness investigations, and large-scale public health emergencies like COVID-19. The intent is to help laboratories remain effective as threats evolve and as testing demand rapidly changes, especially during emergencies when speed, scale, and consistency across jurisdictions become critical.

A major driver behind the funding is the reality that PHLs face persistent, structural challenges that can limit readiness and response. The notice highlights several pressure points: the rapid emergence of new disease threats, fast-moving advances in laboratory technologies and methods, and increasing complexity in data sharing and interoperability between laboratory information systems and other health information systems. It also points to ongoing needs around laboratory safety practices as new technologies are adopted, and around strengthening the laboratory workforce and infrastructure. On top of these technical and operational demands, many PHLs experience chronic fiscal strain and workforce reductions, which can jeopardize their ability to build new capabilities or even maintain essential testing services.

CDC frames this award as part of a broader, multi-pronged approach to deliver COVID-19 related support to PHLs, including resources made available through the American Rescue Plan. The emphasis is not only on meeting immediate pandemic needs, but also on improving the underlying public-private clinical laboratory infrastructure so the country can mount rapid, large-scale responses to future public health emergencies. The program also seeks to move resources quickly during the COVID-19 declared emergency while supporting broad access and opportunity to those resources.

Programmatically, the NOFO focuses on strengthening four major capability areas. First is Science, Management, and Operations, which generally involves improving the laboratory's technical services and the day-to-day operational systems that allow testing and response work to function reliably at scale. Second is Policy, Partnership, and Communication, reflecting the need for strong coordination with public health agencies, healthcare partners, and other stakeholders, plus clear communication pathways so laboratory findings translate into action. Third is Training and Capacity Building, which ties directly to sustaining and expanding the workforce and ensuring staff can keep pace with new methods and emerging threats. Fourth is Laboratory Quality, Safety, and Informatics for Public Health Testing Services, Surveillance and Response, which centers on maintaining high-quality results, safe practices, and modern data systems that support surveillance, situational awareness, and efficient data exchange.

Workforce development is explicitly built into CDC's approach. The opportunity describes plans to expand PHL fellowship programs for laboratory science graduates and to launch a new public health internship program for undergraduate students to gain experience in PHL environments. This reflects an effort to strengthen the talent pipeline while also addressing immediate capacity gaps that become especially visible during surges in testing and response needs.

From the funding and administrative perspective, this is a discretionary cooperative agreement (meaning CDC anticipates substantial involvement in the project beyond simply issuing funds). The administering agency is the Department of Health and Human Services, Centers for Disease Control and Prevention, with involvement from CSELS, and it is associated with CFDA 93.322. The opportunity listing indicates an award ceiling of $3,000,000 and an expectation of one award. The original application timeline shown includes a creation date of September 15, 2022 and an original closing date of October 10, 2022, with electronic submissions due by 11:59 pm Eastern Time on the due date. Eligibility is described as "Others" with additional clarification referenced in the full eligibility text of the announcement.

Overall, the opportunity is aimed at making PHLs more resilient, better staffed, more interoperable, and more capable of delivering high-quality testing and data during routine operations and crisis response alike. The end goal is a stronger laboratory backbone for public health surveillance and decision-making, improving health outcomes in the United States while also supporting global health security through better detection, reporting, and response capacity.

  • The Department of Health and Human Services, Centers for Disease Control - CSELS in the health sector is offering a public funding opportunity titled "CDC-RFA-OE20-2001: Enhancing Public Health Laboratory Capabilities and Increasing Capacity" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.322.
  • This funding opportunity was created on Sep 15, 2022.
  • Applicants must submit their applications by Oct 10, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for CDC RFA OE20 20010301SUPP23

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