Opportunity Information: Apply for PA 18 944
The National Institutes of Health (NIH) funding opportunity titled "Biobehavioral Basis of Chronic Pain (R01 Clinical Trial Optional)" (Funding Opportunity Number PA-18-944) invites research grant applications that aim to explain chronic pain through the combined lens of biology and behavior. The central idea is that chronic pain is not experienced the same way by everyone, even when people share the same diagnosis, and that these differences likely reflect a mix of measurable biological factors and psychosocial or behavioral processes. This announcement encourages studies that connect those layers in a rigorous way, with the goal of improving how chronic pain is defined, measured, and ultimately understood at the individual level.
A key emphasis is on characterizing individual differences using phenotype and genotype information along with other "omics" approaches, which can include measures such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, or related high-dimensional biological profiles. The announcement pairs these biological assessments with careful attention to the sensory and emotional dimensions of pain, recognizing that chronic pain is not just about nociception or tissue signals but also about perception, affect, and the broader experience of suffering and impairment. Projects responsive to this opportunity would typically focus on linking biological signatures to clinically meaningful pain outcomes such as pain intensity, pain sensitivity, pain persistence, disability, mood and anxiety symptoms, sleep disturbance, stress responsivity, and other factors that shape day-to-day functioning and quality of life.
The broader research need this program addresses is a clearer understanding of the mechanisms that drive variability in chronic pain experiences among individuals. By directly relating biological processes to behavioral and emotional components, applicants are expected to help define the "individual-specific burden" of chronic pain, meaning a more precise account of how pain affects a particular person and why. This can support more personalized approaches to assessment and management, even when the FOA is not explicitly limited to treatment development. The mechanism of support is the NIH R01, which is commonly used for mature, hypothesis-driven projects that require substantial, multi-year research efforts. Clinical trials are described as optional, meaning applicants may propose clinical trial activities if they are appropriate to the scientific questions, but non-trial mechanistic and observational designs can also fit, as long as the work aligns with the biobehavioral focus.
The opportunity is categorized as discretionary funding and uses the grant funding instrument. It falls under the Education and Health activity category and references CFDA numbers 93.213, 93.361, 93.393, and 93.846. The sponsoring agency is the NIH. The original closing date listed is 2022-01-07, and the FOA creation date is 2018-10-01. The award ceiling and expected number of awards are not specified in the provided listing, which typically means applicants would need to consult the full NIH FOA text and institute-specific guidance to understand budget expectations and likely award volume.
Eligibility is broad and includes many types of organizations that can contribute to chronic pain research. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where relevant); for-profit organizations other than small businesses; small businesses; and other qualified entities. The FOA also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, Indian/Native American tribal governments other than federally recognized entities, and non-U.S. (foreign) organizations. This wide eligibility reflects NIH interest in supporting diverse research settings and populations, which is particularly relevant in chronic pain given known disparities in pain assessment, treatment access, and outcomes across communities.
Overall, this grant opportunity is designed to move chronic pain research toward a more integrated, person-centered science that links biological mechanisms with behavioral and emotional processes. Competitive applications would generally be expected to use strong measurement strategies across both domains, clearly define the pain condition or chronic illness context being studied, and articulate how the proposed biobehavioral approach will explain individual differences in chronic pain experience beyond what either biology-only or behavior-only models can provide.Apply for PA 18 944
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Biobehavioral Basis of Chronic Pain (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.361, 93.393, 93.846.
- This funding opportunity was created on 2018-10-01.
- Applicants must submit their applications by 2022-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 18 944) also looked into and applied for these:
| Funding Opportunity |
|---|
| Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R21 Clinical Trial Optional) Apply for PA 18 946 Funding Number: PA 18 946 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Applying a Biopsychosocial Perspective to Self-Management of Chronic Pain (R01 Clinical Trial Optional) Apply for PA 18 945 Funding Number: PA 18 945 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Implementation Science for Cancer Control: Developing Centers (P50 Clinical Trial Optional) Apply for RFA CA 19 005 Funding Number: RFA CA 19 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
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